その他のPEG関連試薬

臭素化PEG

Br-PEG-Br

MeO-PEG-Br

ビスヒドロキシ-PEG

ビスヒドロキシ-PEG

メトキシ-PEG-アルコール

メトキシPEG-アルコールはヒドロキシ基を他の官能基に変換可能であり、PEG分子のデザインの基本となる試薬です。表面修飾/溶解性向上/キャッピングなどに用いることが可能です。水溶性を付与し、非特異的な吸着および凝集を防ぎます。また、免疫原性を持たないことが特徴です。

メトキシ-PEG-アルコール

ホルミル-PEG

ホルミル-PEGはアミノ基およびヒドラジドと反応性を持つPEG化試薬です。還元的アミノ化を経て2級アミンに変換されます。水溶性の向上、凝集性の抑制という特性を付与しながら、免疫原性ならびに毒性を低下させます。

ホルミル-PEG

参考文献

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▷ Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures1; A. F. Abdel-Magid, K. G. Carson, B. D. Harris, C. A. Maryanoff and R. D. Shah; J Org Chem 1996; 61: 3849-3862. doi:10.1021/jo960057x

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▷ Design, Synthesis, and Characterization of pH-Sensitive PEG−PE Conjugates for Stimuli-Sensitive Pharmaceutical Nanocarriers: The Effect of Substitutes at the Hydrazone Linkage on the pH Stability of PEG−PE Conjugates; A. A. Kale and V. P. Torchilin; Bioconjug Chem 2007; 18: 363-370. doi:10.1021/bc060228x

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▷ Semisynthetic Analogues of PSC-RANTES, a Potent Anti-HIV Protein; H. Gaertner, R. Offord, P. Botti, G. Kuenzi and O. Hartley; Bioconjug Chem 2008; 19: 480-489. doi:10.1021/bc7003044

▷ Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia; P. R. Hamann, L. M. Hinman, I. Hollander, C. F. Beyer, D. Lindh, R. Holcomb, W. Hallett, H.-R. Tsou, J. Upeslacis, D. Shochat, A. Mountain, D. A. Flowers and I. Bernstein; Bioconjug Chem 2002; 13: 47-58. doi:10.1021/bc010021y

▷ In Vivo Antitumor Activity of the Folate-Conjugated pH-Sensitive Polymeric Micelle Selectively Releasing Adriamycin in the Intracellular Acidic Compartments; Y. Bae, N. Nishiyama and K. Kataoka; Bioconjug Chem 2007; 18: 1131-1139. doi:10.1021/bc060401p

▷ Function and Stability of Abscisic Acid Acyl Hydrazone Conjugates by LC-MS2 of ex Vivo Samples; T. R. Smith, A. J. Clark, R. Napier, P. C. Taylor, A. J. Thompson and A. Marsh; Bioconjug Chem 2007; 18: 1355-1359. doi:10.1021/bc070069x

▷ An Intramolecular Cyclization Reaction Is Responsible for the in Vivo Inefficacy and Apparent pH Insensitive Hydrolysis Kinetics of Hydrazone Carboxylate Derivatives of Doxorubicin; C. C. Lee, A. T. Cramer, F. C. Szoka and J. M. J. Fréchet