その他のPEG関連試薬

Iris Biotech社がご提供可能なその他PEG試薬のご紹介です。臭素化、ビスヒドロキシ、メトキシ-アルコール、ホルミルなど紹介しきれなかった製品をまとめております。



臭素化PEG

Br-PEG-Br


表1. Br-PEG-Br製品一覧
コード 製品名 分子式 CAS 分子量 内容量 名称
PEG1075.0001 Br-PEG-Br - - 10000 1g alpha,omega-Bis-bromo poly(ethylene glycol) (PEG-MW 10.000 Dalton)
PEG1075.0005 Br-PEG-Br - - 10000 5g alpha,omega-Bis-bromo poly(ethylene glycol) (PEG-MW 10.000 Dalton)
PEG1076.0001 Br-PEG-Br - - 2000 1g alpha,omega-Bis-bromo poly(ethylene glycol) (PEG-MW 2.000 Dalton)
PEG1076.0005 Br-PEG-Br - - 2000 5g alpha,omega-Bis-bromo poly(ethylene glycol) (PEG-MW 2.000 Dalton)
PEG1077.0001 Br-PEG-Br - - 20000 1g alpha,omega-Bis-bromo poly(ethylene glycol) (PEG-MW 20.000 Dalton)
PEG1077.0005 Br-PEG-Br - - 20000 5g alpha,omega-Bis-bromo poly(ethylene glycol) (PEG-MW 20.000 Dalton)
PEG1078.0001 Br-PEG-Br - - 3000 1g alpha,omega-Bis-bromo poly(ethylene glycol) (PEG-MW 3.000 Dalton)
PEG1078.0005 Br-PEG-Br - - 3000 5g alpha,omega-Bis-bromo poly(ethylene glycol) (PEG-MW 3.000 Dalton)
PEG1079.0001 Br-PEG-Br - - 6000 1g alpha,omega-Bis-bromo poly(ethylene glycol) (PEG-MW 6.000 Dalton)
PEG1079.0005 Br-PEG-Br - - 6000 5g alpha,omega-Bis-bromo poly(ethylene glycol) (PEG-MW 6.000 Dalton)

MeO-PEG-Br


表2. MeO-PEG-Br製品一覧
コード 製品名 分子式 CAS 分子量 内容量 名称
PEG1131.0001 MeO-PEG-Br - - 10000 1g alpha-Methoxy-omega-bromo poly(ethylene glycol) (PEG-MW 10.000 Dalton)
PEG1131.0005 MeO-PEG-Br - - 10000 5g alpha-Methoxy-omega-bromo poly(ethylene glycol) (PEG-MW 10.000 Dalton)
PEG1132.0001 MeO-PEG-Br - - 2000 1g alpha-Methoxy-omega-bromo poly(ethylene glycol) (PEG-MW 2.000 Dalton)
PEG1132.0005 MeO-PEG-Br - - 2000 5g alpha-Methoxy-omega-bromo poly(ethylene glycol) (PEG-MW 2.000 Dalton)
PEG1133.0001 MeO-PEG-Br - - 20000 1g alpha-Methoxy-omega-bromo poly(ethylene glycol) (PEG-MW 20.000 Dalton)
PEG1133.0005 MeO-PEG-Br - - 20000 5g alpha-Methoxy-omega-bromo poly(ethylene glycol) (PEG-MW 20.000 Dalton)
PEG1134.0001 MeO-PEG-Br - - 5000 1g alpha-Methoxy-omega-bromo poly(ethylene glycol) (PEG-MW 5.000 Dalton)
PEG1134.0005 MeO-PEG-Br - - 5000 5g alpha-Methoxy-omega-bromo poly(ethylene glycol) (PEG-MW 5.000 Dalton)
PEG1135.0001 MeO-PEG-Br - - 750 1g alpha-Methoxy-omega-bromo poly(ethylene glycol) (PEG-MW 750 Dalton)
PEG1135.0005 MeO-PEG-Br - - 750 5g alpha-Methoxy-omega-bromo poly(ethylene glycol) (PEG-MW 750 Dalton)

ビスヒドロキシ-PEG

ビスヒドロキシ-PEG


表3. ビスヒドロキシ-PEG製品一覧
コード 製品名 分子式 CAS 分子量 内容量 名称
PEG1009.0001 HO-PEG(28)-OH C56H114O29 - 1251.49 1g alpha,omega-Bis-hydroxy 28(ethylene glycol)
PEG1009.0005 HO-PEG(28)-OH C56H114O29 - 1251.49 5g alpha,omega-Bis-hydroxy 28(ethylene glycol)
PEG1010.0005 HO-PEG-OH - 25322-68-3 10000 5g alpha,omega-Bis-hydroxy poly(ethylene glycol) (PEG-MW 10.000 Dalton)
PEG1010.0025 HO-PEG-OH - 25322-68-3 10000 25g alpha,omega-Bis-hydroxy poly(ethylene glycol) (PEG-MW 10.000 Dalton)
PEG1011.0005 HO-PEG-OH - 25322-68-3 2000 5g alpha,omega-Bis-hydroxy poly(ethylene glycol) (PEG-MW 2.000 Dalton)
PEG1011.0025 HO-PEG-OH - 25322-68-3 2000 25g alpha,omega-Bis-hydroxy poly(ethylene glycol) (PEG-MW 2.000 Dalton)
PEG1012.0005 HO-PEG-OH - 25322-68-3 20000 5g alpha,omega-Bis-hydroxy poly(ethylene glycol) (PEG-MW 20.000 Dalton)
PEG1012.0025 HO-PEG-OH - 25322-68-3 20000 25g alpha,omega-Bis-hydroxy poly(ethylene glycol) (PEG-MW 20.000 Dalton)
PEG1013.0005 HO-PEG-OH - 25322-68-3 3000 5g alpha,omega-Bis-hydroxy poly(ethylene glycol) (PEG-MW 3.000 Dalton)
PEG1013.0025 HO-PEG-OH - 25322-68-3 3000 25g alpha,omega-Bis-hydroxy poly(ethylene glycol) (PEG-MW 3.000 Dalton)
PEG1014.0005 HO-PEG-OH - 25322-68-3 6000 5g alpha,omega-Bis-hydroxy poly(ethylene glycol) (PEG-MW 6.000 Dalton)
PEG1014.0025 HO-PEG-OH - 25322-68-3 6000 25g alpha,omega-Bis-hydroxy poly(ethylene glycol) (PEG-MW 6.000 Dalton)
PEG1015.0005 HO-PEG(12)-OH C24H50O13 6790-09-6 546.65 5g Dodeca-ethylene glycol
PEG1015.0025 HO-PEG(12)-OH C24H50O13 6790-09-6 546.65 25g Dodeca-ethylene glycol
PEG1016.0005 HO-PEG(8)-OH C16H34O9 5117-19-1 370.44 5g Octa-ethylene glycol
PEG1016.0025 HO-PEG(8)-OH C16H34O9 5117-19-1 370.44 25g Octa-ethylene glycol

メトキシ-PEG-アルコール

メトキシPEG-アルコールはヒドロキシ基を他の官能基に変換可能であり、PEG分子のデザインの基本となる試薬です。表面修飾/溶解性向上/キャッピングなどに用いることが可能です。水溶性を付与し、非特異的な吸着および凝集を防ぎます。また、免疫原性を持たないことが特徴です。

メトキシ-PEG-アルコール


表4. ホルミル-PEG製品一覧
コード 製品名 分子式 CAS 分子量 内容量 名称
PEG1032.0001 MeO-PEG(7)-OH C15H32O8 4437-01-8 340.41 1g Hepta(ethylene glycol) methylether
PEG1032.0005 MeO-PEG(7)-OH C15H32O8 4437-01-8 340.41 5g Hepta(ethylene glycol) methylether
PEG1032.0100 MeO-PEG(7)-OH C15H32O8 4437-01-8 340.41 100mg Hepta(ethylene glycol) methylether
PEG1033.0001 MeO-PEG-OH - 9004-74-4 10000 1g alpha-Methoxy-omega-hydroxy poly(ethylene glycol) (PEG-MW 10.000 Dalton)
PEG1033.0005 MeO-PEG-OH - 9004-74-4 10000 5g alpha-Methoxy-omega-hydroxy poly(ethylene glycol) (PEG-MW 10.000 Dalton)
PEG1034.0005 MeO-PEG-OH - 9004-74-4 2000 5g alpha-Methoxy-omega-hydroxy poly(ethylene glycol) (PEG-MW 2.000 Dalton)
PEG1034.0025 MeO-PEG-OH - 9004-74-4 2000 25g alpha-Methoxy-omega-hydroxy poly(ethylene glycol) (PEG-MW 2.000 Dalton)
PEG1035.0001 MeO-PEG-OH - 9004-74-4 20000 1g alpha-Methoxy-omega-hydroxy poly(ethylene glycol) (PEG-MW 20.000 Dalton)
PEG1035.0005 MeO-PEG-OH - 9004-74-4 20000 5g alpha-Methoxy-omega-hydroxy poly(ethylene glycol) (PEG-MW 20.000 Dalton)
PEG1036.0005 MeO-PEG-OH - 9004-74-4 5000 5g alpha-Methoxy-omega-hydroxy poly(ethylene glycol) (PEG-MW 5.000 Dalton)
PEG1036.0025 MeO-PEG-OH - 9004-74-4 5000 25g alpha-Methoxy-omega-hydroxy poly(ethylene glycol) (PEG-MW 5.000 Dalton)
PEG1037.0005 MeO-PEG-OH - 9004-74-4 750 5g alpha-Methoxy-omega-hydroxy poly(ethylene glycol) (PEG-MW 750 Dalton)
PEG1037.0025 MeO-PEG-OH - 9004-74-4 750 25g alpha-Methoxy-omega-hydroxy poly(ethylene glycol) (PEG-MW 750 Dalton)
PEG1038.0001 MeO-PEG(11)-OH C23H48O12 114740-40-8 516.62 1g Undecae(ethylene glycol) methylether
PEG1038.0005 MeO-PEG(11)-OH C23H48O12 114740-40-8 516.62 5g Undecae(ethylene glycol) methylether
PEG1218.0001 MeO-PEG-OMs - - 5000 1g alpha-Methoxy-omega-mesitylate poly(ethylene glycol) (PEG-MW 5.000 Dalton)
PEG1218.0005 MeO-PEG-OMs - - 5000 5g alpha-Methoxy-omega-mesitylate poly(ethylene glycol) (PEG-MW 5.000 Dalton)
PEG1695.0001 MeO-dPEG(4)-Tos C16H26O7S 62921-76-0 362.44 1g 2,5,8,11-Tetraoxatridecan-13-yl 4-methylbenzenesulfonate
PEG1720.0001 MeO-EG(2)-Tos C12H18O5S 50586-80-6 274.33 1g 2-(2-Methoxyethoxy)ethyl 4-methylbenzenesulfonate
PEG2155.0001 MeO-PEG(4)-OH C9H20O5 23783-42-8 208.25 1g 2,5,8,11-Tetraoxatridecan-13-ol
PEG2155.0100 MeO-PEG(4)-OH C9H20O5 23783-42-8 208.25 100mg 2,5,8,11-Tetraoxatridecan-13-ol
PEG3250.0100 MeO-dPEG™(15)-OH C31H64O16 114740-40-8 692.83 100mg Pentadecae(ethylene glycol) methylether
PEG3250.1000 MeO-dPEG™(15)-OH C31H64O16 114740-40-8 692.83 1g Pentadecae(ethylene glycol) methylether
PEG3260.0100 MeO-dPEG™(19)-OH C39H80O20 114740-40-8 869.04 100mg Nonadecae(ethylene glycol) methylether
PEG3260.1000 MeO-dPEG™(19)-OH C39H80O20 114740-40-8 869.04 1g Nonadecae(ethylene glycol) methylether
PEG3270.0100 MeO-dPEG™(23)-OH C47H96O24 114740-40-8 1045.25 100mg alpha-Methoxy-omega-hydroxy-23(ethylene glycol)
PEG3270.1000 MeO-dPEG™(23)-OH C47H96O24 114740-40-8 1045.25 1g alpha-Methoxy-omega-hydroxy-23(ethylene glycol)
PEG3280.0100 MeO-dPEG™(36)-OH C73H148O37 114740-40-8 1617.93 100mg alpha-Methoxy-omega-hydroxy-36(ethylene glycol)
PEG3280.1000 MeO-dPEG™(36)-OH C73H148O37 114740-40-8 1617.93 1g alpha-Methoxy-omega-hydroxy-36(ethylene glycol)
PEG3820.1000 MeO-dPEG™(7)-Tos C22H38O10S 79622-11-0 494.6 1g alpha-Methoxy-omega-tosyl hepta(ethylene glycol)

ホルミル-PEG

ホルミル-PEGはアミノ基およびヒドラジドと反応性を持つPEG化試薬です。還元的アミノ化を経て2級アミンに変換されます。水溶性の向上、凝集性の抑制という特性を付与しながら、免疫原性ならびに毒性を低下させます。

ホルミル-PEG


表4. ホルミル-PEG製品一覧
コード 製品名 分子式 CAS 分子量 内容量 名称
PEG1141.0001 MeO-PEG-CHO - - 10000 1g alpha-Methoxy-omega-formyl poly(ethylene glycol) (PEG-MW 10.000 Dalton)
PEG1141.0005 MeO-PEG-CHO - - 10000 5g alpha-Methoxy-omega-formyl poly(ethylene glycol) (PEG-MW 10.000 Dalton)
PEG1142.0001 MeO-PEG-CHO - - 2000 1g alpha-Methoxy-omega-formyl poly(ethylene glycol) (PEG-MW 2.000 Dalton)
PEG1142.0005 MeO-PEG-CHO - - 2000 5g alpha-Methoxy-omega-formyl poly(ethylene glycol) (PEG-MW 2.000 Dalton)
PEG1143.0001 MeO-PEG-CHO - - 20000 1g alpha-Methoxy-omega-formyl poly(ethylene glycol) (PEG-MW 20.000 Dalton)
PEG1143.0005 MeO-PEG-CHO - - 20000 5g alpha-Methoxy-omega-formyl poly(ethylene glycol) (PEG-MW 20.000 Dalton)
PEG1144.0001 MeO-PEG-CHO - - 5000 1g alpha-Methoxy-omega-formyl poly(ethylene glycol) (PEG-MW 5.000 Dalton)
PEG1144.0005 MeO-PEG-CHO - - 5000 5g alpha-Methoxy-omega-formyl poly(ethylene glycol) (PEG-MW 5.000 Dalton)
PEG1145.0001 MeO-PEG-CHO - - 750 1g alpha-Methoxy-omega-formyl poly(ethylene glycol) (PEG-MW 750 Dalton)
PEG1145.0005 MeO-PEG-CHO - - 750 5g alpha-Methoxy-omega-formyl poly(ethylene glycol) (PEG-MW 750 Dalton)
PEG1178.0001 OHC-PEG-CHO - - 10000 1g alpha,omega-Bis-formyl poly(ethylene glycol) (PEG-MW 10.000 Dalton)
PEG1178.0005 OHC-PEG-CHO - - 10000 5g alpha,omega-Bis-formyl poly(ethylene glycol) (PEG-MW 10.000 Dalton)
PEG1179.0001 OHC-PEG-CHO - - 2000 1g alpha,omega-Bis-formyl poly(ethylene glycol) (PEG-MW 2.000 Dalton)
PEG1179.0005 OHC-PEG-CHO - - 2000 5g alpha,omega-Bis-formyl poly(ethylene glycol) (PEG-MW 2.000 Dalton)
PEG1180.0001 OHC-PEG-CHO - - 20000 1g alpha,omega-Bis-formyl poly(ethylene glycol) (PEG-MW 20.000 Dalton)
PEG1180.0005 OHC-PEG-CHO - - 20000 5g alpha,omega-Bis-formyl poly(ethylene glycol) (PEG-MW 20.000 Dalton)
PEG1181.0001 OHC-PEG-CHO - - 3000 1g alpha,omega-Bis-formyl poly(ethylene glycol) (PEG-MW 3.000 Dalton)
PEG1181.0005 OHC-PEG-CHO - - 3000 5g alpha,omega-Bis-formyl poly(ethylene glycol) (PEG-MW 3.000 Dalton)
PEG1182.0001 OHC-PEG-CHO - - 6000 1g alpha,omega-Bis-formyl poly(ethylene glycol) (PEG-MW 6.000 Dalton)
PEG1182.0005 OHC-PEG-CHO - - 6000 5g alpha,omega-Bis-formyl poly(ethylene glycol) (PEG-MW 6.000 Dalton)
PEG2170.0001 MeO-PEG(4)-CHO C10H20O5 197513-96-5 220.26 1g alpha-Methoxy-omega-propanal tetra(ethylene glycol)
PEG2170.0100 MeO-PEG(4)-CHO C10H20O5 197513-96-5 220.26 100mg alpha-Methoxy-omega-propanal tetra(ethylene glycol)
PEG2175.0001 MeO-PEG(8)-CHO C18H36O9 1234369-95-9 396.47 1g alpha-Methoxy-omega-propanal octa(ethylene glycol)
PEG2175.0100 MeO-PEG(8)-CHO C18H36O9 1234369-95-9 396.47 100mg alpha-Methoxy-omega-propanal octa(ethylene glycol)
PEG2180.0001 MeO-PEG(24)-CHO C50H100O25 125061-88-3 1101.31 1g alpha-Methoxy-omega-propanal 24(ethylene glycol)
PEG2180.0100 MeO-PEG(24)-CHO C50H100O25 125061-88-3 1101.31 100mg alpha-Methoxy-omega-propanal 24(ethylene glycol)
PEG2335.0001 MeO-PEG(11)-PrCHO C26H52O13 125061-88-3 572.68 1g alpha-Methoxy-omega-propional undeca(ethylene glycol)
PEG2335.0100 MeO-PEG(11)-PrCHO C26H52O13 125061-88-3 572.68 100mg alpha-Methoxy-omega-propional undeca(ethylene glycol)

参考文献

▷ Bioconjugate Techniques; G. T. Hermanson; 2nd Edition; Elsevier 2008; 235-276, 200-202: general discussion on reactions with hydrazides, reductive amination, and the Mannich condensation; 232: protocol for reductive amination with proteins; ISBN 978-0-12-370501-3

▷ Nucleophilic Catalysis of Oxime Ligation; A. Dirksen, T. M. Hackeng and P. E. Dawson; Angew Chem. Int. Ed. 2006; 45: 7581-7584. doi:10.1002/anie.200602877

▷ Rapid Oxime and Hydrazone Ligations with Aromatic Aldehydes for Biomolecular Labeling; A. Dirksen and P. E. Dawson; Bioconjug Chem 2008; 19: 2543-2548. doi:10.1021/bc800310p

▷ Nucleophilic Catalysis of Hydrazone Formation and Transimination: Implications for Dynamic Covalent Chemistry; A. Dirksen, S. Dirksen, T. M. Hackeng and P. E. Dawson; J Am Chem Soc 2006; 128: 15602-15603. doi:10.1021/ja067189k

▷ Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures1; A. F. Abdel-Magid, K. G. Carson, B. D. Harris, C. A. Maryanoff and R. D. Shah; J Org Chem 1996; 61: 3849-3862. doi:10.1021/jo960057x

▷ Monoclonal Antibody Conjugates of Doxorubicin Prepared with Branched Linkers: A Novel Method for Increasing the Potency of Doxorubicin Immunoconjugates; H. D. King, D. Yurgaitis, D. Willner, R. A. Firestone, M. B. Yang, S. J. Lasch, K. E. Hellström and P. A. Trail; Bioconjug Chem 1999; 10: 279-288. doi:10.1021/bc980100i

▷ Design, Synthesis, and Characterization of pH-Sensitive PEG−PE Conjugates for Stimuli-Sensitive Pharmaceutical Nanocarriers: The Effect of Substitutes at the Hydrazone Linkage on the pH Stability of PEG−PE Conjugates; A. A. Kale and V. P. Torchilin; Bioconjug Chem 2007; 18: 363-370. doi:10.1021/bc060228x

▷ High-efficiency labeling of sialylated glycoproteins on living cells; Y. Zeng, T. N. C. Ramya, A. Dirksen, P. E. Dawson and J. C. Paulson; Nat Meth 2009; 6: 207-209. doi:10.1038/nmeth.1305 “SMART” Drug Delivery Systems: Double-Targeted pH-Responsive Pharmaceutical Nanocarriers; R. M. Sawant, J. P. Hurley, S. Salmaso, A. Kale, E. Tolcheva, T. S. Levchenko and V. P. Torchilin; Bioconjug Chem 2006; 17: 943-949. doi:10.1021/bc060080h

▷ Semisynthetic Analogues of PSC-RANTES, a Potent Anti-HIV Protein; H. Gaertner, R. Offord, P. Botti, G. Kuenzi and O. Hartley; Bioconjug Chem 2008; 19: 480-489. doi:10.1021/bc7003044

▷ Gemtuzumab Ozogamicin, A Potent and Selective Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia; P. R. Hamann, L. M. Hinman, I. Hollander, C. F. Beyer, D. Lindh, R. Holcomb, W. Hallett, H.-R. Tsou, J. Upeslacis, D. Shochat, A. Mountain, D. A. Flowers and I. Bernstein; Bioconjug Chem 2002; 13: 47-58. doi:10.1021/bc010021y

▷ In Vivo Antitumor Activity of the Folate-Conjugated pH-Sensitive Polymeric Micelle Selectively Releasing Adriamycin in the Intracellular Acidic Compartments; Y. Bae, N. Nishiyama and K. Kataoka; Bioconjug Chem 2007; 18: 1131-1139. doi:10.1021/bc060401p

▷ Function and Stability of Abscisic Acid Acyl Hydrazone Conjugates by LC-MS2 of ex Vivo Samples; T. R. Smith, A. J. Clark, R. Napier, P. C. Taylor, A. J. Thompson and A. Marsh; Bioconjug Chem 2007; 18: 1355-1359. doi:10.1021/bc070069x

▷ An Intramolecular Cyclization Reaction Is Responsible for the in Vivo Inefficacy and Apparent pH Insensitive Hydrolysis Kinetics of Hydrazone Carboxylate Derivatives of Doxorubicin; C. C. Lee, A. T. Cramer, F. C. Szoka and J. M. J. Fréchet