Cys - 疑似プロリン Cys-擬似プロリンは、tBu/Bocの標準的な切断条件に対して安定です。このことから、複数の環を保有するペプチドの合成において部位特異的ジスルフィド結合を形成する際の優れた戦略が実現可能になります。 表1. システイン - 疑似プロリン製品リスト コード 製品名 分子式 CAS 分子量 内容量 名称 PSI1280.0250 Fmoc-L-Ala-L-Cys[PSI(Me,Me)Pro]-OH C24H26N2O5S - 454.54 250mg (S)-3-(N-(9-Fluorenylmethyloxycarbonyl)-L-alaninyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1280.1000 Fmoc-L-Ala-L-Cys[PSI(Me,Me)Pro]-OH C24H26N2O5S - 454.54 1g (S)-3-(N-(9-Fluorenylmethyloxycarbonyl)-L-alaninyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1290.0250 Fmoc-L-Asp(tBu)-L-Cys[PSI(Me,Me)Pro]-OH C29H34N2O7S - 554.65 250mg (S)-3-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartyl-t-butyl ester)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1290.1000 Fmoc-L-Asp(tBu)-L-Cys[PSI(Me,Me)Pro]-OH C29H34N2O7S - 554.65 1g (S)-3-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-aspartyl-t-butyl ester)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1300.0000 Fmoc-L-Cys(Acm)-L-Cys[PSI(Me,Me)Pro]-OH C27H31N3O6S2 - 557.68 0 (S)-3-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-(acetyl-aminomethyl)-L-cysteinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1310.0250 Fmoc-L-Cys(Trt)-L-Cys[PSI(Me,Me)Pro]-OH C43H40N2O5S2 - 728.92 250mg (S)-3-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-trityl-L-cysteinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1310.1000 Fmoc-L-Cys(Trt)-L-Cys[PSI(Me,Me)Pro]-OH C43H40N2O5S2 - 728.92 1g (S)-3-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-trityl-L-cysteinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1320.0000 Fmoc-L-Cys(Mmt)-L-Cys[PSI(Me,Me)Pro]-OH C44H42N2O6S2 - 758.94 0 (S)-3-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-(4-methoxytrityl)-L-cysteinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1330.0000 Fmoc-L-Glu(tBu)-L-Cys[PSI(Me,Me)Pro]-OH C30H36N2O7S - 568.68 0 (S)-3-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-glutamyl-t-butyl ester)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1340.0000 Fmoc-Gly-L-Cys[PSI(Me,Me)Pro]-OH C23H24N2O5S - 440.51 0 (S)-3-(N-(9-Fluorenylmethyloxycarbonyl)-glycinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1350.0250 Fmoc-L-Ile-L-Cys[PSI(Me,Me)Pro]-OH C27H32N2O5S - 496.62 250mg (S)-3-(N-(9-Fluorenylmethyloxycarbonyl)-L-isoleucinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1350.1000 Fmoc-L-Ile-L-Cys[PSI(Me,Me)Pro]-OH C27H32N2O5S - 496.62 1g (S)-3-(N-(9-Fluorenylmethyloxycarbonyl)-L-isoleucinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1360.0000 Fmoc-L-Leu-L-Cys[PSI(Me,Me)Pro]-OH C27H32N2O5S - 496.62 0 (S)-3-(N-(9-Fluorenylmethyloxycarbonyl)-L-leucinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1370.0250 Fmoc-L-Lys(Boc)-L-Cys[PSI(Me,Me)Pro]-OH C32H41N3O7S - 611.75 250mg (S)-3-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-t-butyloxycarbonyl-L-lysinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1370.1000 Fmoc-L-Lys(Boc)-L-Cys[PSI(Me,Me)Pro]-OH C32H41N3O7S - 611.75 1g (S)-3-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-t-butyloxycarbonyl-L-lysinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1380.0000 Fmoc-L-Phe-L-Cys[PSI(Me,Me)Pro]-OH C30H30N2O5S - 530.63 0 (S)-3-(N-(9-Fluorenylmethyloxycarbonyl)-L-phenylalaninyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1390.0001 Fmoc-L-Ser(tBu)-L-Cys[PSI(Me,Me)Pro]-OH C28H34N2O6S - 526.64 1g (S)-3-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-serinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1390.0250 Fmoc-L-Ser(tBu)-L-Cys[PSI(Me,Me)Pro]-OH C28H34N2O6S - 526.64 250mg (S)-3-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-serinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1400.0000 Fmoc-L-Tyr(tBu)-L-Cys[PSI(Me,Me)Pro]-OH C34H38N2O6S - 602.74 0 (S)-3-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-tyrosinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1410.0250 Fmoc-L-Val-L-Cys[PSI(Me,Me)Pro]-OH C26H30N2O5S - 482.59 250mg (S)-3-(N-(9-Fluorenylmethyloxycarbonyl)-L-valinyl)-2,2-dimethylthiazolidine-4-carboxylic acid PSI1410.1000 Fmoc-L-Val-L-Cys[PSI(Me,Me)Pro]-OH C26H30N2O5S - 482.59 1g (S)-3-(N-(9-Fluorenylmethyloxycarbonyl)-L-valinyl)-2,2-dimethylthiazolidine-4-carboxylic acid 目次 Cys - 疑似プロリン
