光架橋リンカー

Iris Biotech社の試薬およびパーフルオロアジドによる新規光アフィニティラベル法および架橋形成のご紹介です。



アリールアジドはナイトレンのよく知られた前駆体であり、受容体を研究するための幅広い用途を持つ光アフィニティラベリング剤としてFleetらによって報告されました。

光分解されるとN2が遊離され、非常に不安定な一重項フェニルナイトレンが *in situ*で形成されます。多様な反応を介して隣接する分子と反応しますが、同時に環拡大反応や同一分子間の結合反応等も生じます。これに対しペルフルオロフェニルアジドは、高収率で隣接基との挿入反応および付加反応を行う非常に安定なナイトレン中間体を形成します。

このタイプの化合物は、エストロゲン受容体研究や炭素系ポリマー、有機系ポリマーの表面コーティングのために光架橋剤(λmax=258nm)として使用されています。これらの化合物は、従来のクリックケミストリー用試薬として、低分子化合物や生体分子の結合のための光活性化リンカー、さらには表面修飾のための反応基導入およびナノマテリアル合成のために使用することが可能であり、応用分野はかなり幅広いものとなります。

参考文献

▷ Affinity of Antibodies with Aryl Nitrenes as Reactive Group; G.W.J. Fleet, R.R. Porter, J.R. Knowles; Nature 1969; 224: 511-512.

▷ Perfluorophenyl Azides: New Applications in Surface Functionalization and Nanomaterial Synthesis; Li-Hong L iu, Mingdi Yan; Accounts of Chemical Research 2011; 43(11): 1434-1443. DOI 10.1021/ar100066t.

製品一覧


表1. 光架橋リンカー製品一覧
コード 製品名 分子式 CAS 分子量 内容量 名称
HAA2130.0001 N3-L-Dap(Boc)-OH C8H14N4O4 - 230.22 1g (S)-2-Azido-3-((t-butyloxycarbonyl)amino)propanoic acid
HAA2130.0005 N3-L-Dap(Boc)-OH C8H14N4O4 - 230.22 5g (S)-2-Azido-3-((t-butyloxycarbonyl)amino)propanoic acid
HAA2130.0025 N3-L-Dap(Boc)-OH C8H14N4O4 - 230.22 25g (S)-2-Azido-3-((t-butyloxycarbonyl)amino)propanoic acid
HAA2135.0001 N3-D-Dap(Boc)-OH C8H14N4O4 - 230.22 1g (R)-2-Azido-3-((t-butyloxycarbonyl)amino)propanoic acid
HAA2135.0005 N3-D-Dap(Boc)-OH C8H14N4O4 - 230.22 5g (R)-2-Azido-3-((t-butyloxycarbonyl)amino)propanoic acid
HAA2135.0025 N3-D-Dap(Boc)-OH C8H14N4O4 - 230.22 25g (R)-2-Azido-3-((t-butyloxycarbonyl)amino)propanoic acid
HAA2140.0001 N3-L-Dap(Fmoc)-OH C18H16N4O4 880637-82-1 352.34 1g (S)-2-Azido-3-[(9-fluorenylmethyloxycarbonyl)amino]propanoic acid
HAA2140.0005 N3-L-Dap(Fmoc)-OH C18H16N4O4 880637-82-1 352.34 5g (S)-2-Azido-3-[(9-fluorenylmethyloxycarbonyl)amino]propanoic acid
HAA2140.0025 N3-L-Dap(Fmoc)-OH C18H16N4O4 880637-82-1 352.34 25g (S)-2-Azido-3-[(9-fluorenylmethyloxycarbonyl)amino]propanoic acid
HAA2145.0001 N3-D-Dap(Fmoc)-OH C18H16N4O4 1807631-13-5 352.34 1g (R)-2-Azido-3-[(9-fluorenylmethyloxycarbonyl)amino]propanoic acid
HAA2145.0005 N3-D-Dap(Fmoc)-OH C18H16N4O4 1807631-13-5 352.34 5g (R)-2-Azido-3-[(9-fluorenylmethyloxycarbonyl)amino]propanoic acid
HAA2145.0025 N3-D-Dap(Fmoc)-OH C18H16N4O4 1807631-13-5 352.34 25g (R)-2-Azido-3-[(9-fluorenylmethyloxycarbonyl)amino]propanoic acid
HAA2150.0001 N3-L-Dab(Boc)-OH C9H16N4O4 - 244.25 1g (S)-2-Azido-4-((t-butyloxycarbonyl)amino)butanoic acid
HAA2150.0005 N3-L-Dab(Boc)-OH C9H16N4O4 - 244.25 5g (S)-2-Azido-4-((t-butyloxycarbonyl)amino)butanoic acid
HAA2150.0025 N3-L-Dab(Boc)-OH C9H16N4O4 - 244.25 25g (S)-2-Azido-4-((t-butyloxycarbonyl)amino)butanoic acid
HAA2155.0001 N3-D-Dab(Boc)-OH C9H16N4O4 - 244.25 1g (R)-2-Azido-4-((t-butyloxycarbonyl)amino)butanoic acid
HAA2155.0005 N3-D-Dab(Boc)-OH C9H16N4O4 - 244.25 5g (R)-2-Azido-4-((t-butyloxycarbonyl)amino)butanoic acid
HAA2155.0025 N3-D-Dab(Boc)-OH C9H16N4O4 - 244.25 25g (R)-2-Azido-4-((t-butyloxycarbonyl)amino)butanoic acid
HAA2160.0001 N3-L-Lys(Fmoc)-OH C21H22N4O4 473430-12-5 394.42 1g (S)-2-Azido-6-[(9-fluorenylmethyloxycarbonyl)amino]hexanoic acid
HAA2160.0005 N3-L-Lys(Fmoc)-OH C21H22N4O4 473430-12-5 394.42 5g (S)-2-Azido-6-[(9-fluorenylmethyloxycarbonyl)amino]hexanoic acid
HAA2160.0025 N3-L-Lys(Fmoc)-OH C21H22N4O4 473430-12-5 394.42 25g (S)-2-Azido-6-[(9-fluorenylmethyloxycarbonyl)amino]hexanoic acid
HAA2165.0001 N3-D-Lys(Fmoc)-OH C21H22N4O4 - 394.42 1g (R)-2-Azido-3-[(9-fluorenylmethyloxycarbonyl)amino]propanoic acid
HAA2165.0005 N3-D-Lys(Fmoc)-OH C21H22N4O4 - 394.42 5g (R)-2-Azido-3-[(9-fluorenylmethyloxycarbonyl)amino]propanoic acid
HAA2165.0025 N3-D-Lys(Fmoc)-OH C21H22N4O4 - 394.42 25g (R)-2-Azido-3-[(9-fluorenylmethyloxycarbonyl)amino]propanoic acid
HAA2170.0001 N3-L-Lys(Boc)-OH C11H20N4O4 333366-32-8 272.3 1g (S)-2-Azido-6-[(t-butyloxycarbonyl)amino]hexanoic acid
HAA2170.0005 N3-L-Lys(Boc)-OH C11H20N4O4 333366-32-8 272.3 5g (S)-2-Azido-6-[(t-butyloxycarbonyl)amino]hexanoic acid
HAA2170.0025 N3-L-Lys(Boc)-OH C11H20N4O4 333366-32-8 272.3 25g (S)-2-Azido-6-[(t-butyloxycarbonyl)amino]hexanoic acid
HAA2175.0001 N3-D-Lys(Boc)-OH C11H20N4O4 1178899-92-7 272.3 1g (R)-2-Azido-6-[(t-butyloxycarbonyl)amino]hexanoic acid
HAA2175.0005 N3-D-Lys(Boc)-OH C11H20N4O4 1178899-92-7 272.3 5g (R)-2-Azido-6-[(t-butyloxycarbonyl)amino]hexanoic acid
HAA2175.0025 N3-D-Lys(Boc)-OH C11H20N4O4 1178899-92-7 272.3 25g (R)-2-Azido-6-[(t-butyloxycarbonyl)amino]hexanoic acid
HAA2210.0001 N3-D-Orn(Boc)-OH*CHA C10H18N4O4*C6H13N - 258,27*99,18 1g (R)-2-Azido-5-[(t-butyloxycarbonyl)amino]pentanoic acid cyclohexylamine
HAA2210.0005 N3-D-Orn(Boc)-OH*CHA C10H18N4O4*C6H13N - 258,27*99,18 5g (R)-2-Azido-5-[(t-butyloxycarbonyl)amino]pentanoic acid cyclohexylamine
HAA2210.0025 N3-D-Orn(Boc)-OH*CHA C10H18N4O4*C6H13N - 258,27*99,18 25g (R)-2-Azido-5-[(t-butyloxycarbonyl)amino]pentanoic acid cyclohexylamine
HAA2215.0001 N3-D-Orn(Fmoc)-OH C20H20N4O4 - 380.4 1g (R)-2-Azido-5-[(9-fluorenylmethyloxycarbonyl)amino]pentanoic acid
HAA2215.0005 N3-D-Orn(Fmoc)-OH C20H20N4O4 - 380.4 5g (R)-2-Azido-5-[(9-fluorenylmethyloxycarbonyl)amino]pentanoic acid
HAA2215.0025 N3-D-Orn(Fmoc)-OH C20H20N4O4 - 380.4 25g (R)-2-Azido-5-[(9-fluorenylmethyloxycarbonyl)amino]pentanoic acid
HAA2220.0001 N3-L-Orn(Boc)-OH*CHA C10H18N4O4*C6H13N 1639198-67-6 258,27*99,18 1g (S)-2-Azido-5-[(t-butyloxycarbonyl)amino]pentanoic acid cyclohexylamine
HAA2220.0005 N3-L-Orn(Boc)-OH*CHA C10H18N4O4*C6H13N 1639198-67-6 258,27*99,18 5g (S)-2-Azido-5-[(t-butyloxycarbonyl)amino]pentanoic acid cyclohexylamine
HAA2220.0025 N3-L-Orn(Boc)-OH*CHA C10H18N4O4*C6H13N 1639198-67-6 258,27*99,18 25g (S)-2-Azido-5-[(t-butyloxycarbonyl)amino]pentanoic acid cyclohexylamine
HAA2225.0001 N3-L-Orn(Fmoc)-OH C20H20N4O4 - 380.4 1g (S)-2-Azido-5-[(9-fluorenylmethyloxycarbonyl)amino]pentanoic acid
HAA2225.0005 N3-L-Orn(Fmoc)-OH C20H20N4O4 - 380.4 5g (S)-2-Azido-5-[(9-fluorenylmethyloxycarbonyl)amino]pentanoic acid
HAA2225.0025 N3-L-Orn(Fmoc)-OH C20H20N4O4 - 380.4 25g (S)-2-Azido-5-[(9-fluorenylmethyloxycarbonyl)amino]pentanoic acid
HAA2230.0001 N3-1,4-cis-CHC-OH C7H11N3O 863222-21-3 169.18 1g cis-4-Azidocyclohexanecarboxylic acid
HAA2230.0005 N3-1,4-cis-CHC-OH C7H11N3O 863222-21-3 169.18 5g cis-4-Azidocyclohexanecarboxylic acid
HAA2230.0025 N3-1,4-cis-CHC-OH C7H11N3O 863222-21-3 169.18 25g cis-4-Azidocyclohexanecarboxylic acid
HAA2235.0001 N3-1,4-trans-CHC-OH C7H11N3O2 - 169.18 1g trans-4-Azidocyclohexanecarboxylic acid
HAA2235.0005 N3-1,4-trans-CHC-OH C7H11N3O2 - 169.18 5g trans-4-Azidocyclohexanecarboxylic acid
HAA2235.0025 N3-1,4-trans-CHC-OH C7H11N3O2 - 169.18 25g trans-4-Azidocyclohexanecarboxylic acid
HAA2240.0001 N3-trans-MCHC-OH C8H13N3O2 - 183.21 1g trans-4-(Azidomethyl)cyclohexanecarboxylic acid
HAA2240.0005 N3-trans-MCHC-OH C8H13N3O2 - 183.21 5g trans-4-(Azidomethyl)cyclohexanecarboxylic acid
HAA2240.0025 N3-trans-MCHC-OH C8H13N3O2 - 183.21 25g trans-4-(Azidomethyl)cyclohexanecarboxylic acid
HAA2255.0100 N3-Cystamine-Suc-OSu C12H17N5O5S2 - 375.42 100mg 4-(2-((2-Azidoethyl)disulfanyl)ethylamino)-4-oxobutanoic acid succinimidyl ester
HAA2255.0250 N3-Cystamine-Suc-OSu C12H17N5O5S2 - 375.42 250mg 4-(2-((2-Azidoethyl)disulfanyl)ethylamino)-4-oxobutanoic acid succinimidyl ester
HAA2255.0500 N3-Cystamine-Suc-OSu C12H17N5O5S2 - 375.42 500mg 4-(2-((2-Azidoethyl)disulfanyl)ethylamino)-4-oxobutanoic acid succinimidyl ester
HAA2255.1000 N3-Cystamine-Suc-OSu C12H17N5O5S2 - 375.42 1g 4-(2-((2-Azidoethyl)disulfanyl)ethylamino)-4-oxobutanoic acid succinimidyl ester
HAA2280.0250 N3-L-Dbu(Boc)-OH C9H16N4O4 - 244.25 250mg (R)-3-Azido-4-((t-butyloxycarbonyl)amino)butanoic acid
HAA2280.1000 N3-L-Dbu(Boc)-OH C9H16N4O4 - 244.25 1g (R)-3-Azido-4-((t-butyloxycarbonyl)amino)butanoic acid
HAA2280.5000 N3-L-Dbu(Boc)-OH C9H16N4O4 - 244.25 5g (R)-3-Azido-4-((t-butyloxycarbonyl)amino)butanoic acid
PEG1935.0001 Propargyl-NHS C10H11NO5 1174157-65-3 225.2 1g 3-(Prop-2-ynyloxy)propanoic acid succinimidyl ester
PEG1935.0100 Propargyl-NHS C10H11NO5 1174157-65-3 225.2 100mg 3-(Prop-2-ynyloxy)propanoic acid succinimidyl ester
RL-2055.0100 Alkyne-myristic acid C14H24O2 82909-47-5 224.34 100mg 13-Tetradecynoic acid
RL-2055.0500 Alkyne-myristic acid C14H24O2 82909-47-5 224.34 500mg 13-Tetradecynoic acid
RL-2055.1000 Alkyne-myristic acid C14H24O2 82909-47-5 224.34 1g 13-Tetradecynoic acid
RL-2060.0100 Alkyne-palmitic acid C16H28O2 99208-90-9 252.39 100mg 15-Hexadecynoic acid
RL-2060.0500 Alkyne-palmitic acid C16H28O2 99208-90-9 252.39 500mg 15-Hexadecynoic acid
RL-2060.1000 Alkyne-palmitic acid C16H28O2 99208-90-9 252.39 1g 15-Hexadecynoic acid
RL-2065.0100 Alkyne-stearic acid C18H32O2 34450-18-5 280.45 100mg 17-Octadecynoic acid
RL-2065.0500 Alkyne-stearic acid C18H32O2 34450-18-5 280.45 500mg 17-Octadecynoic acid
RL-2065.1000 Alkyne-stearic acid C18H32O2 34450-18-5 280.45 1g 17-Octadecynoic acid